The show is entirely driven by the acerbic, blunt character of Dr. House, played masterfully by Hugh Laurie. He's one of my favourite actors with a huge range of talent (including humour: notably Blackadder and Jeeves and Wooster where he plays an utter fop ) and the ability to melt into a role like this. IMDB says:
During Hugh Laurie's audition, David Shore says that Bryan Singer, one of the executive producers, said, "See, this is what I want: an American guy." Singer was completely unaware of the fact that Laurie is English.Also, Robert Sean Leonard is still cute. Awww, those puppy-dog eyes.
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But don't you find the repetitious mechanisms a bit tedious? I mean, they always break into the patient's house to see if there's an environmental pathogen. And they always drive the patient almost to death with the wrong treatments. And even then, the answer is never reached by a logical assembly of the clues, with an "Aha!" and a victory — House always comes up with some off-the-wall guess, like he sees a sardine can in the garbage in the cafeteria, and that makes him think of Sardinian Ovine Blastocystitis, and he decides that the patient must have tupped a sheep on Sardinia and contracted SOB, and it always turns out to be the right answer, la-la-la. That doesn't bother you?
— Also, Robert Sean Leonard is still cute.
Ahhhh, now we have it. But he has three names, which means he's an assassin. (See here and look a few quotes down for an explanation of that non-sequitur.)
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