The show is entirely driven by the acerbic, blunt character of Dr. House, played masterfully by Hugh Laurie. He's one of my favourite actors with a huge range of talent (including humour: notably Blackadder and Jeeves and Wooster where he plays an utter fop ) and the ability to melt into a role like this. IMDB says:
During Hugh Laurie's audition, David Shore says that Bryan Singer, one of the executive producers, said, "See, this is what I want: an American guy." Singer was completely unaware of the fact that Laurie is English.Also, Robert Sean Leonard is still cute. Awww, those puppy-dog eyes.